New York Yankees designated hitter Giancarlo Stanton has suffered a moderate-grade left calf strain, a significant setback that manager Aaron Boone said Saturday has left his availability for the remainder of the season very much in question.

The injury occurred during a running drill a couple of days prior, according to Boone. Stanton was in the process of rehabbing a right calf issue and was close to rejoining the lineup before the new strain.

"What that means moving forward, we're not ruling anything out," Boone said, per multiple outlets. "He'll obviously continue to work to try and get it right and hopefully be available, but obviously we're at a point in the calendar where it gets challenging. But you also never know."

A Season of Setbacks

The latest injury is just one chapter in a frustrating 2026 campaign for the veteran slugger. Stanton has not played for the Yankees since late April, when he sustained a right calf strain while running the bases during a win over the Houston Astros on April 24.

He landed on the injured list three days later and was in the middle of his rehab when he suffered a set back in the same right leg in June. He had only recently resumed running the bases in early August. While the sources vary on the exact timeline of the earlier injury, it was clear Stanton was close to a return.

"You all know how bad he wants to be on that field, contributing to a championship," Boone said.

Boone Expresses Sympathy for Stanton

Boone expressed sympathy for the 36-year-old, who has been limited to just 24 games this season, all as a designated hitter.

"Obviously, bummed for him," Boone said, according to several reports. "Been working his tail off every single day here, trying to get this thing right. I think you all know how bad he wants to be on that field, contributing to a championship. Obviously, that's disappointing. Hopefully, we'll just continue to work to get him right and healthy."

Stanton, a vocal presence in the clubhouse, remains a key figure despite his absence from the field. "He's in our hitters meetings every day," Boone said. "He's in the trenches with the guys as much as he can be. I admire him so much, who he is and the way he goes about things."

On-Field Struggles Continue

The news of Stanton's injury overshadowed a difficult day on the field for the Yankees, who saw their five-game win streak snapped with a 4-3 loss to the Toronto Blue Jays at home on Saturday. The team managed just two hits on the afternoon, both coming in the seventh inning or later. The Yankees lost despite a late rally attempt, to fall to 73-56 on the season.

Manager Aaron Boone is also navigating additional pitching concerns. Ryan Weathers exited Saturday's game with left forearm discomfort.

Adding to the team's injury woes, the Yankees are also without outfielder Aaron Judge, who continues to rehab and has not played since May 31.