Experimental Ebola Drugs Shipped to DR Congo as Outbreak Surpasses 1,000 Cases
The United States has begun shipping experimental Ebola treatments to the Democratic Republic of Congo (DRC), where an outbreak has caused more than 1,000 confirmed cases and over 250 deaths, according to the World Health Organization (WHO) and US officials.
The US Department of Health and Human Services confirmed it will provide doses of MBP134, an antibody drug developed by California-based Mapp Biopharmaceutical, for compassionate use in the DRC and to support a clinical trial in the outbreak region. A department spokesperson told Reuters that the drug is being made available for compassionate use in Congo as well as to advance a clinical trial in the outbreak area.
Previously, Washington had said doses of the drug would only be made available to its own citizens considered at high risk after exposure to the virus. The spokesperson added that trial data could help support future regulatory review and possible US approval, but declined to say how many doses were being provided.
The outbreak, caused by the Bundibugyo strain of Ebola, has no approved vaccines or treatments. The DRC has recorded more than 1,000 confirmed cases since the outbreak was confirmed on 15 May. The Africa Centre for Strategic Studies warned that the number of cases has risen faster than in any previous Ebola outbreak on record.
The WHO said shipments of MBP134 and other treatments intended for trials are already on their way. The agency is working with health partners to prepare trial enrolment at treatment facilities in the affected region. Trials of the Mapp drug and two antivirals developed by US pharmaceutical company Gilead Sciences are due to begin in the coming weeks, according to information provided by the WHO and scientists involved in the testing.
The outbreak is concentrated in the northeastern DRC, with more than 97 percent of cases in Ituri, North Kivu and South Kivu provinces. The DRC has announced free healthcare for all illnesses in Ituri as the Ebola outbreak continues to gain ground.
Health officials anticipate that running trials and delivering care in the eastern DRC will be difficult due to challenges such as disease testing, contact tracing, supply chain disruptions, mistrust, and attacks on health workers.