ET at Paycor Stadium in Cincinnati on FOX. The Buccaneers come into this game fresh off agreeing to a new three-year extension with quarterback Baker Mayfield, who has been the team's starter for the past three seasons after taking over for Tom Brady and has gone 27-24 in that span. The Buccaneers lost longtime wide receiver Mike Evans but strengthened their defense with first-round pick defensive end Rueben Bain Jr.

The Bengals, who have had one of the most talented teams in the AFC yet seem to get undone each season by injuries — particularly to quarterback Joe Burrow — finished 6-11 last season. Cincinnati has missed the playoffs in three straight seasons and has reached the postseason just once since making the Super Bowl in the 2021 season. The Bengals will need defensive end Myles Murphy and defensive tackle Dexter Lawrence II to step up after losing edge rusher Trey Hendrickson this offseason to divisional rival Baltimore. Lawrence II, whom the Bengals acquired for their 2026 first-round pick, was their major offseason acquisition.

ET. The moneyline has the Buccaneers at +170 (bet $100 to win $170) and the Bengals at -210 (bet $210 to win $100). Against the spread, the Buccaneers are +3.5 (-108) and the Bengals are -3.5 (-110). The over/under is set at 50.5 points (over -108, under -110).

A separate preview from Sports Illustrated, with odds via FanDuel Sportsbook, lists similar spreads and totals, with the Buccaneers at +3.5 (-105) and the Bengals at -3.5 (-115) on the spread, the moneyline at Buccaneers +168 and Bengals -200, and the over/under at 50.5 (over -112, under -108).

Injury Report

Four Buccaneers players are listed on the injury report. Wide receiver Jalen McMillan (knee) is doubtful, linebacker Christian Rozeboom (foot) is questionable, tackle Justin Skule (oblique) is doubtful, and running back Sean Tucker (hamstring) is doubtful. For the Bengals, defensive end Shemar Stewart (knee) is doubtful.

Betting Trends and Predictions

Cincinnati is 0-3 against the spread in its last three season-opening games. The Bengals' recent slow starts are part of a broader pattern in the Zac Taylor era, according to Sports Illustrated's analysis. The Buccaneers, meanwhile, have covered the spread in four of their last five meetings with the Bengals, a trend noted in the same outlet. The Buccaneers finished the 2025 season going 1-9 against the spread in their last 10 games, while the Bengals finished 5-5 against the spread in their last 10 games.

The consensus prediction from the USA TODAY Network previews (appearing in the Asbury Park Press, Sioux Falls Argus Leader, The Arizona Republic, Burlington Free Press, Cincinnati Enquirer, Asheville Citizen-Times, Fort Collins Coloradoan, Des Moines Register, Fayetteville Observer, Detroit Free Press, Gainesville Sun, Erie Times-News, Green Bay Press-Gazette, Herald-Tribune, Naples Daily News, Springfield News-Leader, northjersey.com, Athens Banner-Herald, Quincy Patriot Ledger, Peoria Journal Star, Reno Gazette-Journal, Savannah Morning News, South Bend Tribune, TCPalm, Worcester Telegram & Gazette, Ventura County Star, and York Daily Record) is a Bengals 27, Buccaneers 24 victory. Those previews note that the Bengals (-210) are too expensive to take on the moneyline and that the Buccaneers (+170) are better played on the spread.

Burrow should be able to have his way through the air, especially after the Bengals were able to keep both wide receivers Ja'Marr Chase and Tee Higgins, according to those outlets. At the same time, the Buccaneers boast a top-10 offensive line and have the weapons in receivers Chris Godwin and Emeka Egbuka to put strain on a Bengals secondary that remains unproven. With Stewart likely out, the Bengals won't be able to get much pressure on Mayfield, allowing him to dominate, the previews argue.

Sports Illustrated offers a contrarian view on the spread, recommending a bet on the Buccaneers +3.5 (-105) via FanDuel. The analysis notes that the Bengals have a history of starting slow in the Zac Taylor era and expresses doubt about whether Cincinnati has addressed its defensive issues. Joe Burrow, who is healthy and back in the Bengals lineup, sits near the top of the odds list to win his first career NFL MVP, the same preview states, while Baker Mayfield is described as fresh and ready for a statement campaign.

Key Players to Watch

Joe Burrow is the pivotal figure for Cincinnati, having appeared in just eight games last season due to injury. In his starts, he completed 66.8% of his passes for 1,809 yards, 17 touchdowns, and five interceptions, per Sports Illustrated. For Tampa Bay, Mayfield returns under a new contract and with the team's core receiving corps largely intact, though without Evans.

Kickoff is scheduled for 1 p.m. ET at Paycor Stadium in Cincinnati.