An Amazon Prime Air Boeing 767-300 cargo plane overran the runway at Miami International Airport on Sunday afternoon, striking multiple vehicles and catching fire, according to officials. Several people were injured in the incident.

The aircraft, operating as 21 Air Flight 7598, departed from Luis Muñoz Marín International Airport in San Juan, Puerto Rico, and was landing at Miami around 2 p.m. local time when it went off the runway, the Federal Aviation Administration (FAA) said in a statement. The FAA confirmed the plane was an Amazon Prime Air aircraft and said it would investigate the crash.

Miami-Dade Aviation confirmed the plane overran the airport's diagonal runway and stopped at the northwest end of the airport, where it remained disabled. The airport said all runways and taxiways were closed as of 3 p.m., and a ground stop was issued for arriving and departing flights.

Video and photos from the scene, widely shared on social media and captured by local news outlets, showed the aircraft sitting off the runway with its tail over a fence, thick black smoke rising from the fuselage, and flames visible. The plane appeared to be largely intact despite the fire, which firefighters worked to extinguish.

Miami-Dade Fire Rescue (MDFR) reported "multiple patients" and said more than 60 of its units responded to the scene. The fire department said the plane hit several vehicles near the 2100 block of Northwest 42nd Avenue. The Miami-Dade Sheriff's Office said it was also responding.

US Transportation Secretary Sean Duffy said on X that responders would "assess the scene after an Amazon cargo plane overran the runway," adding that travelers should expect significant delays and potential cancellations.

Kelly Nantel, an Amazon spokesperson, said: "We can confirm that an Amazon Air plane operated by 21 Air experienced an incident while attempting to land at Miami International Airport [Sunday]." Amazon did not immediately respond to requests for comment from NPR or FOX 4 News.

The FAA said the ground stop, initially issued until 3:30 p.m., was later extended until 4:30 p.m. About 250 flights were delayed at the airport as of late afternoon, according to flight-tracking website FlightAware, as reported by the South China Morning Post.

Officials had not released information on injuries or deaths as of Sunday evening, according to the South China Morning Post and The Guardian. The National Transportation Safety Board was not immediately mentioned in the reports, but The Guardian said it had reached out to the agency for comment.