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Merck and Moderna announced that their personalized mRNA vaccine, intismeran, combined with Keytruda, reduced recurrence and spread of melanoma in a late-stage trial, the first positive Phase 3 result for an mRNA-based cancer therapy. Shares of Moderna more than doubled, while Merck also gained, as the companies prepare to discuss regulatory filings.
Sen. Darline Graham, appointed to fill her late brother Lindsey Graham's seat, faces Rep. Ralph Norman in Tuesday's GOP runoff after admitting during a debate she is 'not that informed on national security.' President Trump has backed Graham, while critics question her readiness for a full Senate term.
The US Justice Department has defended its prosecution of former FBI director James Comey over a social media post showing seashells arranged to read '8647', arguing in court filings that the post could be read as a threat against President Donald Trump. Prosecutors said the decision to indict Comey was made by a local US attorney without direction from senior leadership, while Comey's lawyers and PEN America argue the post was protected speech.
Florida Governor Ron DeSantis suspended Michael Caruso, a former close ally and Palm Beach County clerk of court, after his arrest on felony child sexual abuse charges. Caruso faces five charges including kidnapping and child molestation, with allegations involving a male relative under 12. DeSantis called the allegations 'truly horrific' and said the decision to suspend was easy.
India's export dependence on the US stayed largely unchanged at around 20% in the 12 months through July, despite tariffs that reached 50% and diversification efforts. Commerce ministry data show US-bound shipments rose to $87.31 billion in 2025-26, while trade experts warn diversification will take years.
Russia and Ukraine exchanged 103 prisoners of war each on August 19, 2026, in a swap mediated by the United Arab Emirates. Ukrainian President Zelensky confirmed the return of servicemen from several branches, while Russian officials reported that freed soldiers were in Belarus for medical care. Another exchange is expected before the end of the month.
Iran's armed forces warned Gulf countries on Wednesday against assisting the U.S. military, hours after the United Arab Emirates announced it was halting all trade and financial dealings with Iran following an alleged missile attack. The UAE accused Iran of firing two ballistic missiles at its territory on Tuesday, a claim Tehran denied. The escalation comes amid a broader U.S.-Iran conflict centered on the Strait of Hormuz, with oil prices rising above $90 per barrel.
Prosecutors say an inscription on a bullet recovered from the murder weapon "Hey Facist! CATCH!" shows conservative activist Charlie Kirk was targeted for his politics, a key factor as they seek the death penalty. The defense disputes the political motive and has asked the judge to ban cameras from an upcoming hearing, arguing it could become a "reality TV show." A judge will hear arguments on September 1.
David Morens, a former senior adviser to Dr. Anthony Fauci at the National Institute of Allergy and Infectious Diseases, pleaded guilty to conspiring to hide federal records during the COVID-19 pandemic. The plea stems from an alleged scheme to evade public records laws and restore a terminated bat coronavirus research grant. Sentencing is scheduled for November 12, and he faces up to five years in prison.
The US and South Korea have ended their annual Ulchi Freedom Shield exercises about a week early after President Donald Trump ordered the drills scaled back, citing his relationship with Kim Jong Un. The move drew criticism from North Korea and raised questions in Seoul about its implications for the alliance.
U.S. President Donald Trump paused the rollout of 50% tariffs on Canadian goods for three days, announcing the reprieve on Truth Social and citing a potential deal. The pause comes after negotiations collapsed over the weekend, with both sides blaming each other for the breakdown.
The US and Canada have reached a tentative trade deal, prompting President Trump to pause planned 50% tariffs on Canadian goods for three days. Negotiators are finalising details, with both leaders expressing optimism despite unresolved issues.
The United States and South Korea have agreed to end their annual Ulchi Freedom Shield exercise about a week early, following President Trump's order to scale back the drills. North Korea's Kim Yo-jong dismissed the reduction as insignificant, while political reactions in Seoul have deepened domestic divisions and tensions with Pyongyang.
The annual Ulchi Freedom Shield exercise between the US and South Korea ended five days early after President Trump ordered a reduction, citing relations with North Korea and cost. The scaled-back drills drew criticism from experts and North Korea, while the US confirmed preparation for the trilateral Freedom Edge exercise in 2026.
Trade negotiations between the US and Canada collapsed at the last minute, triggering 50% US tariffs on about $20 billion of Canadian goods. Canada's Prime Minister Mark Carney announced retaliatory tariffs, matching the US measures 'dollar for dollar', set to take effect on September 8.
Six people deported by the U.S. to Liberia refused to get off the plane and were instead flown to Equatorial Guinea, where they are held in a hotel without medical staff and face deteriorating conditions, according to a fellow deportee and a lawyer.
The United Arab Emirates has halted all trade, commercial exchanges and financial transactions with Iran indefinitely, accusing Iranian forces of firing two ballistic missiles at its territory. Iran denied the allegation, calling it a 'false flag operation' by the US and Israel, as tensions continue to disrupt shipping through the Strait of Hormuz and keep energy prices elevated.
A coalition of US unions and higher-education groups has filed a lawsuit seeking to block a Department of Homeland Security rule that would cap how long foreign students, exchange visitors, and journalists can stay without extensions. The rule, set to take effect September 15, has prompted universities to urge students to return early, while a federal court hearing is scheduled for September 3.
The United States imposed 50% tariffs on $20 billion of Canadian goods after negotiations failed, prompting Canada to promise retaliatory measures starting September 8. Both sides blame each other for the breakdown, raising concerns about the future of North American trade relations.
US President Donald Trump paused 50% tariffs on Canadian goods for three days after reaching a tentative deal, but the future remains uncertain. The pause follows tense negotiations and promises further discussions, with both sides claiming progress while differences persist.